Jazz Pharmaceuticals (Jazz) is committed to improving patient outcomes and providing support in compliance with local regulations.
Therapeutic Areas of Interest
Acute Myeloid Leukemia (AML)
- The role of intensive chemotherapy in the treatment of secondary AML
- Identification and timely, actionable diagnosis of high-risk AML subsets (e.g., AML-MRC, tAML)
- Different technologies for the delivery of secondary AML treatments
- Treatment of secondary AML to include:
- Efficacy
- Safety
- Impact on quality of life
- Depth of response, real world data and long-term outcomes
- Treatment of secondary AML to include:
- Appropriate management of secondary AML patients in the in-patient and out-patient setting
- The AML treatment paradigm (e.g., induction, consolidation, combination therapy, maintenance therapy) and
patient management - Clinical and economic burden of secondary AML
- Recognition, incidence, risk factors, diagnosis and early intervention of VOD/SOS including in the
non-transplant setting - VOD/SOS diagnostic criteria, diagnostic techniques, radiologic findings and severity grading in both adult and
pediatric patients - Pathophysiology, progressive nature and life-threatening complications of advanced VOD/SOS and other endothelial related complications
- Efficacy, safety and mechanism of action of current therapies and patient management for the
treatment of VOD/SOS - Clinical and economic burden of VOD/SOS and other post-transplant complications associated with endothelial
cell damage - Efficacy and safety of current therapies and patient management for COVID-19 related ARDS and other endotheliitis
- The biology of immune response, differentiation and management of asparaginase hypersensitivity reaction vs. infusion reaction and the impact and burden on safety and efficacy
- The importance of completing treatment and potential safety or other concerns associated with current clinical mitigation strategies for hypersensitivity reactions
- Recognition and management of asparaginase toxicities in the adult/young adult population
- Management of pediatric and adult/young adult ALL/LBL with asparaginase (e.g., monitoring, PK, safety,
clinical value) - Pediatric inspired protocols in the adult/young adult population
- The efficacy and clinical benefits of new asparaginase formulation in ALL/LBL
- Asparaginase therapies and combinations beyond ALL/LBL